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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Circulation. 2014 Feb 11;129(17):1761–1769. doi: 10.1161/CIRCULATIONAHA.113.007913

Figure 5.

Figure 5

Morphometric consequences of vascular COX-2 deletion on lesion development. Lesion morphology in aortic roots from female mice fed HFD for 6 months were analyzed. Quantification of immunohistochemical staining of collagen (A), laminin (B), α-SMA (C) and VCAM-1 (D) from each genotype are shown in parallel with their representative aortic root sections. One-way ANOVA (Kruskal-Wallis test) revealed a significant effect of genotype (P<0.05) on lesion morphology. Dunnett’s multiple comparison tests were used to test significant differences between WT and COX-2 KOs. Data are means ± SEMs. n=4-5 per genotype. L- lumen, m- media, nc- necrotic core, fc- foam cell.