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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Free Radic Biol Med. 2014 Jan 17;70:155–166. doi: 10.1016/j.freeradbiomed.2014.01.015

Figure 11.

Figure 11

IL-1b is induced by CSE through C3a interacting with the receptor C3aR, and this induction is magnified by Nrf2-KD. A) Graph showing increased IL-1b mRNA, as measured by RT-qPCR, after 125μg/ml CSE, with magnified expression when combined with Nrf2-KD. B) Graph showing increased secreted IL-1b protein, as measured by ELISA, after 125μg/ml CSE, with magnified expression when combined with Nrf2-KD. C) Graph showing IL-1b mRNA induction is mediated by C3aR. ARPE-19 cells were transfected with siRNA control siRNA or siRNA Nrf2 and then DMSO vehicle control or 125μg/ml CSE for 24h. Some cells were treated with the C3aR antagonist SB290157 (1μM; C3aRA). n=3 ind exp for all assays. *p<0.05, **p<0.01, ***p<0.001.

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