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Conserved role of the shutter region for RCL insertion into the A β-sheet. A, Sequence alignment of selected residues of the shutter region between Spn42Da and neuroserpin. Highlighted residues and hydrogen bonding network of the shutter region in native neuroserpin (PDB code 3FGQ [18]) (B) and cleaved Spn42Da (C). Spn42Da 2mFo-Dfc maps displayed as blue mesh contoured at 2.0 σ and putative hydrogen bonds displayed as red dashed lines.
