Table 2.

Relative affinities of antipsychotics drugs at some neurotransmitter receptors relevant to metabolic side effects [30]

Dopamine D2 Ki (nM)	Haloperidol 2.0	Clozapine 431	Olanzapine 72	Risperidone 4.9	Paliperidone 9.4	Quetiapine 567	Ziprasidone 4.0	Aripiprazole 0.95	Asenapine 1.0
α1A-adrenergic	0.17 [12]	270 [1.6]	0.66 [109]	0.98 [5.0]	3.8 [2.5]	25 [22]	0.22 [18]	0.038 [25]	1.1 [1.2]
α2A-adrenergic	< 10-2 [>1000]	3.0 [142]	0.24 [314]	0.032 [151]	2.0 [4.7]	0.16 [3600]	0.025 [160]	0.012 [74]	[1.3]
Histamine H1	< 10-2 [>1000]	220 [2.0]	15 [4.9]	0.96 [5.2]	1.7 [5.6]	76 [7.5]	0.031 [130]	0.032 [28]	1.3 [1.0]
Muscarinic M3	< 10-2 [>1000]	17 [25]	1.4 [51]	< 10-2 [>104]	< 10-2 [>104]	0.29 [1943]	< 10-2 [>1000]	< 10-2 [>1000]	< 10-2 [>1000]
5-HT1A	< 10-2 [>1000]	4.1(a) [105]	0.036 [2063]	0.011 [427]	0.015 [640]	1.3(a) [430]	0.053(a) [76]	0.17(a) [5.6]	0.52(a) [2.5]
5-HT1B	0.012 [165]	1.1 [398]	0.14 [509]	0.091 [53.6]	0.087 [109]	0.52 [1109]	1.0(a) [4.0]	< 10-2 [830]	0.33 [4.0]
5-HT2A	0.035 [57]	81 [5.35]	30 [3.37]	29 [0.17]	4.9 [1.9]	2.8 [200]	13 [0.30]	0.11 [8.7]	18 [0.071]
5-HT2C	< 10-2 [>1000]	46 [9.44]	7.2 [10.2]	0.41 [12]	0.20 [48]	0.22 [2500]	0.31 [13]	0.043(a) [22.4]	37 [0.035]
5-HT6	< 10-2 [>1000]	25 [17]	12 [6.0]	< 10-2 [>1000]	< 10-2 [>1000]	0.30 [1864]	0.066 [61]	< 10-2 [642]	5.2 [0.25]