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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Behav Pharmacol. 2014 Jun;25(3):216–225. doi: 10.1097/FBP.0000000000000039

Figure 1.

Figure 1

(A) Effects of pre- and post-retrieval mifepristone (RU486; RU) on social play-induced CPP. The experimental protocol is depicted above the graph (Pre-C: pre-conditioning test, CS+: conditioning session with a play-partner, CS−: conditioning session alone). Data represent the mean time (s + SEM) spent in the social compartment (grey and black bars) and the non-social compartment (white bars) during 15 min retrieval- (RETR), test- (TEST) and reinstatement- (REIN) sessions. Vehicle-treated animals (VEH: 2 ml/kg, s.c., n= 32), mifepristone-treated animals (30 mg/kg, s.c., treatment pre-retrieval: Rupre, n=:9; treatment post-retrieval: Rupost: n= 24). (B) Effects of mifepristone on social play-induced CPP in the absence of memory-retrieval. Vehicle-treated animals (VEH; 2ml/kg, i.p., n= 6), mifepristone-treated animals (RU, 30 mg/kg, i.p., n= 10). Post-hoc Student's paired t-tests for difference in time spent in the social- and non-social compartment *p<0.05, **p<0.01, ***p<0.001.