Table 2.
Multivariate analysis of the change in titers in CSF (A) and serum (B)
| A. CSF | p | Estimate | 95% CI | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome | Good | 0.049 | 129 | 75 | 221 | ||||
| Poor | 340 | 158 | 735 | ||||||
| Tumor | No | 0.0079 | 110 | 57 | 213 | ||||
| Yes | 395 | 211 | 750 | ||||||
| time point | First | < 0.0001 | 614 | 347 | 1086 | ||||
| Intermediate | 198 | 118 | 330 | ||||||
| Last | 76 | 46 | 125 | ||||||
| interactions | |||||||||
| tumor * time point | 0.058 | tumor | no tumor | ||||||
| First | 1054 | 469 | 2368 | 358 | 161 | 796 | |||
| Intermediate | 305 | 147 | 633 | 129 | 62 | 268 | |||
| Last | 194 | 96 | 395 | 29 | 14 | 60 | |||
| outcome * tumor | 0.60 | ||||||||
| outcome * time point | 0.55 | ||||||||
| outcome * tumor * time point | 0.45 | ||||||||
| B. serum | p | Estimate | 95% CI | |||
|---|---|---|---|---|---|---|
| Outcome | Good | 0.0025 | 1243 | 655 | 2334 | |
| Poor | 7370 | 3119 | 17243 | |||
| Tumor | No | 0.024 | 1644 | 785 | 3447 | |
| Yes | 5515 | 2684 | 11443 | |||
| time point | First | < 0.0001 | 5460 | 2908 | 10149 | |
| Intermediate | 3214 | 1091 | 5515 | |||
| Last | 1564 | 921 | 2684 | |||
| interactions | ||||||
| tumor * time point | 0.18 | |||||
| outcome * tumor | 0.21 | |||||
| outcome * time point | 0.42 | |||||
| outcome * tumor * time point | 0.13 | |||||
The ln (titer) was used to correct for skewing. After creation of the best fitting model, recalculation of the estimated titer (and confidence interval) was performed; therefore the confidence interval is skewed. CSF cerebrospinal fluid; CI confidence interval