Table 2.

Participant characteristics (mean ± SD or %) by quintile of NT-proBNP, LITE

ARIC
NT-proBNP Quintile		1	2	3	4	5*
Range (pg/ml)		≤ 25.6	25.7–48.3	48.4–80.2	80.3–136.9	≥137.0
N		1908	1910	1909	1909	1907
Age, years		60.2 ± 5.0	61.8 ± 5.4	62.6 ± 5.5	63.3 ± 5.5	64.8 ± 5.7
Female, %		38.0	50.0	62.0	68.8	70.6
African American, %		37.4	22.9	19.9	16.0	16.1
BMI, kg/m2		29.5 ± 5.0	28.8 ± 5.2	28.6 ± 5.4	28.1 ± 5.6	27.9 ± 5.8
Diabetes, %		19.3	15.2	14.1	12.5	13.5
eGFR, ml/min/1.73m2		88.9 ± 20.4	83.6 ± 18.7	81.1 ± 19.0	79.0 ± 18.2	73.9 ± 18.9
CRP, mg/L		3.57 ± 4.43	3.96 ± 5.43	4.17 ± 6.05	4.40 ± 6.17	5.52 ± 8.83
CHS
NT-proBNP Quintile		1	2	3	4	5*
Range (pg/ml)		≤ 46.9	47.0–82.5	82.6–133.5	133.6–237.1	≥237.2
N		833	835	833	834	833
Age, years		70.8 ± 4.2	71.4 ± 4.4	72.4 ± 5.0	73.8 ± 5.5	76.4 ± 6.2
Female, %		51.9	61.3	63.6	68.1	62.8
African American, %		23.5	15.8	14.3	14.3	13.7
BMI, kg/m2		27.4 ± 4.4	27.1 ± 4.7	26.6 ± 4.5	26.1 ± 4.7	25.6 ± 4.6
Diabetes, %		17.3	15.3	14.3	12.8	13.8
eGFR, ml/min/1.73m2		70.9 ± 15.7	69.5 ± 15.3	67.1 ± 15.3	65.8 ± 16.0	59.5 ± 16.8
CRP, mg/L		3.04 ± 4.11	3.26 ± 5.78	2.80 ± 4.03	3.34 ± 5.31	4.15 ± 6.68

^*All linear trends in risk factors across the NT-proBNP quintiles are statistically significant at p<0.0001.