Table 3.

Hazard ratios (95% CIs) for venous thromboembolism according to categories of Troponin T (TnT), LITE

ARIC
TnT Category		1	2	3	4	5	P-trend
Range (ng/L)		< 3	3 to ≤ 5	5 to ≤ 8	8 to ≤ 13	≥ 13
N		3252	2463	1928	1223	685
Total VTE
N events		58	42	44	39	24
Incidence rate per 1000 person-yrs		2.15	2.08	2.87	4.11	4.86
Model 1		1.00	0.94 (0.63, 1.41)	1.26 (0.84, 1.91)	1.76 (1.13, 2.74)	2.09 (1.24, 3.51)	0.0007
Model 2		1.00	0.92 (0.61, 1.38)	1.15 (0.75, 1.74)	1.40 (0.88, 2.22)	1.65 (0.95, 2.87)	0.04
Model 3		1.00	1.02 (0.66, 1.57)	1.23 (0.78, 1.95)	1.39 (0.82, 2.35)	1.66 (0.87, 3.16)	0.08
Unprovoked VTE
N events		21	11	22	17	3
Model 2		1.00	0.70 (0.33, 1.49)	1.69 (0.88, 3.27)	1.72 (0.81, 3.68)	0.64 (0.17, 2.32)	0.32
Provoked VTE
N events		37	31	22	22	21
Model 2		1.00	1.02 (0.63, 1.66)	0.86 (0.50, 1.50)	1.23 (0.68, 2.21)	2.16 (1.15, 4.06)	0.06
Model 2, not cancer related		1.00	1.45 (0.72, 2.93)	1.14 (0.51, 2.57)	1.75 (0.75, 4.09)	3.99 (1.70, 9.41)	0.007
Model 2, cancer related		1.00	0.73 (0.37, 1.44)	0.66 (0.31, 1.42)	0.87 (0.38, 2.00)	1.03 (0.37, 2.82)	0.86
CHS
N		1463	594	742	687	636	P-trend
Total VTEa
N events		41	11	33	25	28
Incidence rate per 1000 person-yrs		2.74	1.86	4.67	4.03	6.11
Model 1		1.00	0.65 (0.33, 1.26)	1.58 (0.98, 2.53)	1.25 (0.73, 2.13)	1.87 (1.09, 3.21)	0.01
Model 2		1.00	0.60 (0.30, 1.20)	1.47 (0.90, 2.38)	1.14 (0.66, 1.96)	1.70 (0.97, 2.99)	0.05
Model 3		1.00	0.56 (0.26, 1.20)	1.27 (0.73, 2.21)	0.98 (0.53, 1.82)	1.48 (0.78, 2.83)	0.74
Unprovoked VTE
N events		15	4	12	11	7
Model 2		1.00	0.46 (0.13, 1.59)	1.29 (0.58, 2.91)	1.15 (0.48, 2.74)	0.93 (0.33, 2.61)	0.74
Provoked VTE
N events		26	7	21	14	21
Model 2		1.00	0.69 (0.30, 1.59)	1.58 (0.86, 2.88)	1.11 (0.55, 2.24)	2.29 (1.17, 4.51)	0.03
Model 2, not cancer related		1.00	0.78 (0.28, 2.13)	1.49 (0.69, 3.10)	0.95 (0.37, 2.42)	2.79 (1.22, 6.38)	0.04
Model 2, cancer related		1.00	0.53 (0.12, 2.43)	1.73 (0.66, 4.56)	1.38 (0.47, 4.05)	1.51 (0.45, 5.11)	0.33
POOLED - ARIC + CHS
N		4715	3057	2670	1910	1321	P-trend
Total VTE
N events		99	53	77	64	52
Incidence rate per 1000 person-yrs		2.36	2.03	3.44	4.08	5.46
Model 1		1.00	0.85 (0.61, 1.19)	1.36 (1.00, 1.86)	1.51 (1.07, 2.12)	1.98 (1.36, 2.87)	<.0001
Model 2		1.00	0.83 (0.59, 1.17)	1.25 (0.91, 1.72)	1.28 (0.90, 1.81)	1.70 (1.15, 2.51)	0.004
Model 3		1.00	0.87 (0.61, 1.26)	1.22 (0.86, 1.73)	1.18 (0.80, 1.76)	1.63 (1.04, 2.56)	0.03
Unprovoked VTE
N events		36	15	34	28	10
Model 2		1.00	0.61 (0.33, 1.15)	1.48 (0.89, 2.46)	1.41 (0.80, 2.48)	0.84 (0.38, 1.82)	0.37
Provoked VTE
N events		63	38	43	36	42
Model 2		1.00	0.95 (0.63, 1.44)	1.11 (0.74, 1.67)	1.19 (0.76, 1.87)	2.27 (1.43, 3.59)	0.003

Model 1: Adjusted for age, sex, and race.

Model 2: Adjusted for Model 1 + diabetes status, BMI, eGFR and CRP.

Model 3: Adjusted for Model 2 + time-dependent censoring of CHD or heart failure during follow-up.

^aThree CHS events had missing data for TnT.