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. 2014 Mar 21;3(5):620–631. doi: 10.5966/sctm.2013-0151

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Figure 6. — Cell counts of mature neurons, medium spiny neurons, and colocalization with transplanted iPSCs. A significant between-group difference in the number of NeuN-positive cells in the area around the transplant site (A) was observed. It was revealed that 3-NP rats that received iPSC transplantation at 7 days had a significantly greater amount of NeuN-positive cells than the 3-NP rats that did receive transplants or the 3-NP rats receiving transplantation at either 21 or 42 days. A significant between-group difference was found in the number of transplanted iPSC cells colocalizing with NeuN (B). It was found that the 7-day transplantation group had more iPSCs colocalized with NeuN than either the 21- or 42-day group. A significant between-group difference was observed in the number of DARPP32-positive cells in the area around the transplant site (C). It was found that 3-NP rats receiving iPSC transplantation at 21 days had significantly more DARPP32-positive cells than 3-NP control rats. However, no between-group differences were observed in the number of iPSCs colocalizing with DARPP32 (D). (∗, Significantly different from sham rats, p < .05; †, significantly different from 3-NP rats, p < .05; #, significantly different from 3-NP iPSC 7-day rats, p < .05.) Abbreviations: 3-NP, 3-nitropropionic acid; iPSC, induced pluripotent stem cell; NeuN, neuronal nuclei.