Table 2.
Statistical power of 2LOmb to detect genetic heterogeneity in small-scaled simulated data sets with different numbers of available SNPs, different numbers of causative SNPs and different ratios of case samples from two affected groups
| |
|
Statistical power |
|||
|---|---|---|---|---|---|
| |
|
20 SNPs |
1,000 SNPs |
||
|
Number of |
Ratio |
At least |
Two |
At least |
Two |
|
causative |
of case |
one interaction |
interactions |
one interaction |
interactions |
| SNPs | samples | detected | detected | detected | detected |
| 2&2 |
1:3 |
1.00 |
0.95 |
1.00 |
0.55 |
| |
1:1 |
1.00 |
1.00 |
1.00 |
1.00 |
| 3&3 |
1:3 |
1.00 |
1.00 |
1.00 |
0.88 |
| |
1:1 |
1.00 |
1.00 |
1.00 |
1.00 |
| 4&4 |
1:3 |
1.00 |
1.00 |
1.00 |
1.00 |
| |
1:1 |
1.00 |
1.00 |
1.00 |
1.00 |
| 2&3 |
1:3 |
1.00 |
0.93 |
1.00 |
0.60 |
| |
1:1 |
1.00 |
1.00 |
1.00 |
1.00 |
| |
3:1 |
1.00 |
0.98 |
1.00 |
0.94 |
| 2&4 |
1:3 |
1.00 |
0.94 |
1.00 |
0.63 |
| |
1:1 |
1.00 |
1.00 |
1.00 |
1.00 |
| |
3:1 |
1.00 |
1.00 |
1.00 |
0.99 |
| 3&4 |
1:3 |
1.00 |
1.00 |
1.00 |
0.88 |
| |
1:1 |
1.00 |
1.00 |
1.00 |
1.00 |
| 3:1 | 1.00 | 1.00 | 1.00 | 0.97 | |
Each data set consists of balanced case-control samples of size 1,600. The results indicate that 2LOmb detects at least one interaction in every data set (global p-value < 0.0001).