Table 2.
Initial meropenem pharmacokinetic parameters
| Patient N° | V ss | V ss /weight | V ss2 / V ss | AUC | Cl | T 1/2 | Peak | Trough | T > 2 mg/L | T > 4 mg/L | T > 8 mg/L |
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
L |
L/Kg |
% |
L/mg.h |
mL/min |
h |
mg/L |
mg/L |
100% |
90% |
70% |
| 1 |
19.6 |
0.25 |
50.6% |
157.1 |
106.7 |
2.9 |
63.3 |
3.0 |
100% |
100% |
100% |
| 2 |
NA |
NA |
NA |
264.7 |
63.3 |
1.5 |
NA |
11.9 |
100% |
100% |
100% |
| 3 |
13.6 |
0.21 |
56.3% |
253.3 |
65 |
2.6 |
94.1 |
8.6 |
100% |
100% |
85% |
| 4 |
13.6 |
0.17 |
78.4% |
160.1 |
103.3 |
1.7 |
102.3 |
4.8 |
100% |
85% |
50% |
| 5 |
13.4 |
0.16 |
51.8% |
129.2 |
128.3 |
1.3 |
80.1 |
2.7 |
100% |
90% |
65% |
| 6 |
32.7 |
0.42 |
93.7% |
134.9 |
123.3 |
3.4 |
52.0 |
3.0 |
100% |
100% |
100% |
| 7 |
18.6 |
0.23 |
73.6% |
479.2 |
35 |
6.4 |
84.7 |
NA |
100% |
100% |
100% |
| 8 |
14.9 |
0.25 |
88.7% |
465.9 |
35 |
5.0 |
91.3 |
NA |
100% |
100% |
75% |
| 9 |
6.7 |
0.07 |
90.4% |
232.5 |
71.7 |
1.4 |
192.5 |
4.4 |
100% |
75% |
50% |
| 10 |
13.0 |
0.16 |
58.4% |
139.5 |
120 |
1.5 |
85.1 |
2.4 |
100% |
75% |
50% |
| 11 |
20.9 |
0.30 |
68,6% |
107.3 |
155 |
1.9 |
58.6 |
2.9 |
100% |
100% |
100% |
| 12 |
13.6 |
0.18 |
79.2% |
304.2 |
55 |
3.5 |
119.8 |
8.6 |
75% |
50% |
35% |
| 13 |
17.1 |
0.27 |
34.9% |
81.4 |
205 |
1.3 |
56.9 |
0.6 |
100% |
100% |
55% |
| 14 |
22.5 |
0.28 |
53.1% |
120.7 |
138.3 |
2.1 |
48.4 |
4.1 |
100% |
100% |
100% |
| 15 |
13.0 |
0.13 |
68.6% |
315.3 |
53.3 |
3.3 |
124.2 |
12.5 |
100% |
90% |
70% |
|
Geometric mean |
15.7 |
0.2 |
63.1% |
190.2 |
73.3 |
2.3 |
85.9 |
3.8 |
100% |
100% |
100% |
| 95% CI | 12.7-19.4 | 0.15-0.27 | 52.7-75.5% | 138.4-261.4 | 45-120 | 1.8-3.1 | 69.2-106.6 | 2.3-6.2 |
Vss – Volume of distribution at steady state; Vss2 - Volume of distribution at steady state (peripheral compartment); AUC – Area under the concentration-time curve; Cl – Meropenem clearance; T1/2 – Half life; NA- Data not available; IQR – Interquartile range; 95% CI - 95% confidence interval of the mean; T > - Percentage of time that meropenem concentration was above 2, 4 and 8 mgL.