Figure 1.

Representative histopathology in UUO rats treated with or without PTX (Massone stain, ×400). Day 3 after ligation, renal tubular dilation with flattened epithelium and without atrophy or thickness of tubular basement membrane accompanied with few fibrosis in interstitial space. Day 7 after ligation, some tubular atrophy and thickness of tubular basement membrane accompanied with moderate fibrosis in interstitial space. Day 14 after ligation, diffused tubular atrophy and thickness of tubular basement membrane accompanied with severe fibrosis in interstitial space.