Figure 1.

H₂O₂ elevates [Ca²⁺]_i across two kinetic patterns in a concentration-dependent manner. In the presence of 1 mmol/L Ca²⁺ in the extracellular solution, H₂O₂ was applied to recorded hepatocytes at the concentrations of 50 μmol/L (A), 100 μmol/L (B), 400 μmol/L (C) and 1 mmol/L (D), and the effects on [Ca²⁺]_i were evaluated. The horizontal bar in each trace indicates the exposure period to H₂O₂. Representative traces are typical case from 5−12 experiments tested.