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Role of the PLC pathway in H2O2-induced elevation of [Ca2+]i. (A) Hepatocytes were pre-treated with 1 μmol/L U73122 for 30 min and then stimulated with 1 mmol/L H2O2 in the presence of 1 mmol/L Ca2+. (B) Direct measurements of PLC activity during exposure to different concentrations of H2O2 showed that only 1 mmol/L H2O2 significantly increased PLC activity. Each column represents the average from 5 experiments and the vertical bars represent SD. cP<0.01 vs control.
