Table 4.
Estimated risk for lymph node metastasis with estrogen receptor-α genotypes
| LN metastasis (n= 156) | ||||
| Genotype | Absent (n = 92) | Present (n = 64) | P | OR (95% CI) |
| Single site | ||||
| Codon 10a | ||||
| 00 | 44 (54%) | 37 (46%) | 1.0 (reference) | |
| 01 | 35 (63%) | 21 (37%) | 0.194 | 0.7 (0.36–1.43) |
| 11 | 13 (68%) | 6 (32%) | 0.6 (0.19–1.59) | |
| Codon 325b | ||||
| 00 | 16 (50%) | 16 (50%) | 1.0 (reference) | |
| 01 | 43 (53%) | 38 (47%) | 0.013 | 0.9 (0.39–2.00) |
| 11 | 33 (77%) | 10 (23%) | 0.3 (0.11–0.82) | |
| Codon 594c | ||||
| 00 | 56 (53%) | 49 (47%) | 1.0 (reference) | |
| 01 | 32 (71%) | 13 (29%) | 0.062 | 0.5 (0.22–0.98) |
| 11 | 4 (67%) | 2 (33%) | 0.6 (0.10–3.26) | |
| Dual sites | ||||
| codon 325:codon 594 | ||||
| 00:00 | 12 (43%) | 16 (57%) | 1.00 (reference) | |
| 01:00 or 00:01 | 29 (49%) | 30 (51%) | 0.001 | 0.78 (0.31–1.92) |
| 01:01 or 11:00 or 00:11 | 35 (71%) | 14 (29%) | 0.30 (0.11–0.79) | |
| 01:11 or 11:01 or 11:11 | 16 (80%) | 4 (20%) | 0.19 (0.05–0.71) | |
aGenotype 00, TCT/TCT; genotype 01, TCT/TCC; genotype 11, TCC/TCC. bGenotype 00, CCC/CCC; genotype 01, CCC/CCG; genotype 11, CCG/CCG. cGenotype 00, ACG/ACG; genotype 01, ACG/ACA; genotype 11, ACA/ACA. LN, lymph node.