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Changes in cardiac weight index (the right, septum and left ventricle) and QTcd were found by isoproterenol (ISO) medication for 10 days in rats. These were reversed by 3 d intervention with either an endothelin receptor antagonist CPU0213 or aminoguanidine (AMI). (A) Heart weight index; (B) Dispersion of QTc (QTcd). n=6−10. Mean±SD. bP<0.05, cP<0.01 vs normal; eP<0.05,fP<0.01 vs ISO.
