Table 1.

Cat transgenesis: founder pregnancies and outcomes

Transgenic cat namea	Vector	Total embryos transferred per vector	Transfers per vector	Pregnancy	Transgenic status	Product of unique oocyte	Sex, age of transgenic kitten
Cats
TgCat1	TBDmGpT	346	9	A	Yes	Yes	Male, 27 months
TgCat2	TBDmGpT			A	Yes	Yes	Male, 27 months
TgCat3	TSinT2AG	325	8	B	Yes	Yes	Female, 12 months
TgCat4	TSinG	128	3	D	Yes	Yes	Male, died at birth
TgCat5	TSinT2AG	b	b	E	Yes	Yes	Female, stillbornc
	TBDmGpR	97	2	None
Pre-term
TgPre1	TSinG	d	d	C	Yes	Yes
TgPre2	TSinG	d	d	C	Yes	Yes
TgPre3	TSinG	d	d	C	Yes	Yes
TgPre4	TSinG	d	d	C	Yes	Yes
TgPre5	TSING	d	d	C	Unknowne	Unknowne
Pre6	TSinT2AG	b	b	B	Nof	Yes
TgPre7	TSinT2AG	b	b	E	Yes	Yes
Totals		996	22	5	10/11	11/11

^aFifteen to twenty-five embryos, each a product of a microinjected oocyte, were transferred per fallopian tube for a total of 30–50 per transfer; 22 such transfers resulted in pregnancies (A–E). Ages are as of July 2011.

^bIncluded in totals for vector TSinT2AG above.

^cTgCat5 was stillborn after placental abruption occurred, though it was fully developed and ultrasound examination the day before birth showed a normal heartbeat; TgPre7 was not viable ultrasonographically and was developmentally arrested at about day 50 of gestation.

^dIncluded in totals for vector TSinG above.

^eDay 45 radiography in pregnancy C showed five fetuses. They were born about 10 d prematurely, on 51–53 d of gestation, with morphology and size appropriate for this late stage. TgPre5 was consumed by the surrogate mother and could not be analyzed.

^fAn underdeveloped, non-transgenic fetus delivered 6 h after TgCat3. No pregnancies resulted from two transfers of TBDmGpR vector-transduced embryos into queens.