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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Psychopharmacology (Berl). 2013 Jul 9;230(4):509–524. doi: 10.1007/s00213-013-3178-6

Fig. 4. Extinction and reinstatement of nicotine seeking in perinatal HFD and Chow offspring.

Fig. 4

(A) Mean ± SEM number of responses on the previously active lever during the first 14 sessions of the extinction phase. (B) During extinction training, lever responding led to saline infusions and the illumination of the cue light previously paired with nicotine. Mean ± SEM number of responses on the previously active lever during reinstatement training induced by a priming injection of saline or nicotine (0.15 mg/kg, s.c.). During reinstatement training, lever responding was not reinforced with nicotine. * Represents significant differences between saline and nicotine treatment (p<0.05). # Represents significant differences between HFD and Chow diet animals (p<0.05). Abbreviations: HFD - high-fat diet.