Table 2.
Effects of perinatal HFD exposure on the binding of [125I]-epibatidine and [125I]-bungarotoxin in the brain of offspring
| [125I]-epibatidine | [125I] bungarotoxin | |||
|---|---|---|---|---|
| Brain Areas | Perinatal Chow | Perinatal HFD | Perinatal Chow | Perinatal HFD |
| mPFC | 180.2 ± 6.5 | 171.2 ± 4.2 | 117.3 ± 3.1 | 121.9 ± 5.7 |
| NAc Sh | 162.5 ± 4.8 | 159.6 ± 2.3 | ----- | ----- |
| NAc Cr | 170.5 ± 3.1 | 168.1 ± 2.7 | ----- | ----- |
| PVN | ----- | ----- | 170.3 ± 6.1 | 168.0 ± 8.5 |
| PVT | 180.9± 1.2 | 176.6± 4.6 | ----- | ----- |
| Zl | 153.0 ± 14.2 | 174.6 ± 4.5 | ||
| LH | ----- | ----- | 137.8 ± 6.7 | 164.3 ± 7.9* |
| VMH | ----- | ----- | 129.9 ± 9.7 | 159.3 ± 6.5* |
| CeA | ----- | ----- | 177.6 ± 15.7 | 192.2 ± 4.3 |
| VTA | 154.7 ± 12.8 | 184.5 ± 5.8* | ----- | ----- |
| SNc | 145.3± 11.5 | 175.0 ± 8.5* | ----- | ----- |
All values are expressed as fmol/mg brain protein, with an asterisk(*) representing a significant effect of diet on nAChR binding (p<0.05) and dashes representing brain regions where limited or no ligand binding was observed.
Abbreviations: mPFC - medial prefrontal cortex; NAc Sh - nucleus accumbens shell; NAc Cr - nucleus accumbens core; PVN - hypothalamic paraventricular nucleus; PVT - thalamic paraventricular nucleus; ZI - zona incerta; LH - lateral hypothalamus; VMH - vebtromedial hypothalamus; CeA - central nucleus of the amygdale; VTA - ventral tegmental area; and SNc - substantia nigra pars compacta.