Table 1. Feature descriptions.

# Dimensions	Features	Descriptions
22	FoldX energy terms	22 energy values from FoldX output
3	OPUS terms	3 terms from OPUS
1	ASA	Naccess ASA of mutated residue
1	Interaction energy	FoldX interaction energy of mutated residue
3	Goap terms	3 terms from Goap
1	Geometric score	Energy score from Geometric
1	Dfire2 term	Energy from Dfire2
1	Dcomplex term	Energy score from Dcomplex

A 33-dimensional feature vector calculated for each nsSNP in both labeled and unlabeled sets. Each feature represents the difference in values of the corresponding terms calculated for the wild-type and mutant PPI complexes.