Table 1. Median and 95% confidence interval (CI) estimates of the rate of change of marginal effect of benzene exposure below 1 ppm (/ – see equations (9) and (12)) and above 1 ppm (/ - see equations (10) and (13)) and the change in absolute rate of change of the marginal effects from below 1 ppm to above 1 ppm (/ – see equations (11) and (14)) for the first two principal components of the Acute Myeloid Leukemia pathway and six chosen genes of interest.

	/βg,1		/βg,2		/δg
Pathway/Gene	Median	95% CI	Median	95% CI	Median	95% CI
Acute Myeloid Leukemia: Principal Component 1	0.333	(0.008, 0.394)	−0.006	(−0.016, 0.002)	0.328	(0.019, 0.380)
Acute Myeloid Leukemia: Principal Component 2	0.106	(−0.244,0.349)	−0.024	(−0.040,0.010)	0.108	(−0.012,0.353)
RUNX1	0.07	(0.018, 0.158)	0.004	(−0.008, 0.025)	0.063	(0.010, 0.151)
FLT3	−0.079	(−0.204, −0.012)	0	(−0.005, 0.004)	0.078	(0.011, 0.202)
CEBPA	−0.877	(−1.11, −0.584)	0.03	(0.006, 0.069)	0.847	(0.561, 1.068)
LEF1	0.032	(−0.035, 0.120)	−0.009	(−0.019, −0.002)	0.025	(−0.008, 0.106)
CYP2E1	0.051	(−0.004, 0.147)	−0.002	(−0.007, 0.002)	0.049	(0.002, 0.146)
CYP2F1	0.002	(−0.033, 0.03)	−0.001	(−0.004, 0.001)	0.008	(−0.001, 0.038)