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. 2014 May 1;10(5):e1004346. doi: 10.1371/journal.pgen.1004346

Figure 4. Transgenerational inheritance of glucose phenotypes requires H3K4me3 components.

Figure 4

(A) N2 animals treated with 2% GE had an increased H3K4me3 mark and this effect was lost in subsequent generations. (B–C) GE delayed late onset paralysis in P0 but not in F1 generation of mTDP-43; set-2(ok952) (B) and mTDP-43; wdr-5.1(ok1417) (C) animals compared to untreated control and this protection was lost in F1 generation. (D–E) Stress resistance was increased in P0 but not in F1 generation of COMPASS (Complex Proteins Associated with Set1) mutants (D) set-2(ok952) and (E) wdr-5.1(ok1417). (F–G) Total progeny numbers were reduced in P0 but not in F1 generations of (F) set-2 and (G) wdr-5.1 mutants.