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. 2014 May 1;10(5):e1004347. doi: 10.1371/journal.pgen.1004347

Figure 4. MetR is epistatic to other longevity treatments involving TOR1 inhibition.

Figure 4

(A and B) Chronological aging of MET2 and MET15 deletion strains deleted for TOR1. Cell survival of 500 cells plated at given time points, normalized to cell survival on day one (n = 6). Chronological aging of MET2 (C) and MET15 (D) deletion strains treated with indicated amounts of rapamycin (Rap). Cell survival of 500 cells plated at given time points, normalized to cell survival on day one (n = 3). Autophagy was measured by means of ALP activity with a fluorescent plate reader (Tecan, Genios Pro) and normalized to untreated controls at indicated time points (also compare to Figure 3C) (E) (n = 4). See also Figure S5.