Table 3.
Univariate Analysis for Nephrotoxicity
| Variable |
Nephrotoxicity
|
p value | |
|---|---|---|---|
| Yes (n = 24) | No (n = 152) | ||
| Age (years), mean ± SD | 60 ± 19 | 57 ± 17 | 0.43 |
|
| |||
| Weight (kg), mean ± SD | 74.5 ± 17.6 | 72.9 ± 17.1 | 0.68 |
|
| |||
| Baseline CrCl (mL/min), mean ± SD | 103.3 ± 49 | 100.4 ± 48.9 | 0.79 |
|
| |||
| Baseline SCr* (μmol/L), mean ± SD | 84.6 ± 43.1 | 84.5 ± 38 | > 0.99 |
|
| |||
| Duration of vancomycin treatment, mean ± SD | |||
| In days | 24.8 ± 16.1 | 17.5 ± 10.3 | 0.044 |
| In weeks* | 3.8 ± 2.2 | 2.9 ± 1.3 | 0.080 |
|
| |||
| Clinical area, no. (%) of patients | |||
| Medicine* | 16 (67) | 68 (45) | 0.046 |
| ICU | 2 (8) | 14 (9) | 0.90 |
|
| |||
| Type of infection treated, no. (%) of patients | |||
| Osteomyelitis or septic arthritis | 5 (21) | 32 (21) | 0.90 |
| Pneumonia | 5 (21) | 19 (12) | 0.31 |
| Febrile neutropenia† | 2 (8) | 2 (1) | 0.032 |
|
| |||
| Organisms identified, no. (%) of patients | |||
| MRSA | 12 (48) | 78 (51) | 0.76 |
| MSSA† | 2 (8) | 2 (1) | 0.032 |
| Enterococcus | 3 (12) | 10 (7) | 0.34 |
|
| |||
| Comorbidity, no. (%) of patients | |||
| Diabetes mellitus | 6 (25) | 30 (20) | 0.62 |
| Hypertension | 9 (38) | 49 (32) | 0.71 |
| Gastrointestinal comorbidity | 6 (25) | 16 (11) | 0.056 |
| Malignancy | 6 (25) | 15 (10) | 0.044 |
| HIV infection | 0 (0) | 20 (13) | 0.059 |
| Sepsis | 0 (0) | 20 (13) | 0.059 |
|
| |||
| Concurrent nephrotoxin, no. (%) of patients | |||
| Any | 11 (46) | 102 (67) | 0.043 |
| ACE inhibitor or ARB* | 1 (4) | 36 (24) | 0.029 |
| IV contrast dye† | 2 (8) | 40 (26) | 0.054 |
| NSAID | 1 (4) | 25 (16) | 0.10 |
ACE = angiotensin-converting enzyme, ARB = angiotensin receptor blocker, CrCl = creatinine clearance, ICU = intensive care unit, MRSA = methicillin-resistant Staphylococcus aureus, MSSA = methicillin-sensitive Staphylococcus aureus, NSAID = nonsteroidal anti-inflammatory drug, SCr = serum creatinine, SD = standard deviation.
*
Variables included in multivariate logistic regression.
†
Excluded from multivariate logistic regression (even though p < 0.1) because of the small number of patients affected.