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. 2014 May 1;9(5):e95154. doi: 10.1371/journal.pone.0095154

Figure 2. CaMKIV sub-model and parameterization.

Figure 2

(A) Reaction diagram of CaMKIV sub-model. Shaded gray ovals highlight the molecules used for constraining the model. (B) Time course of activation of CaMKIV by CaMKK [38]. (C) Calmodulin dependence of CaMKIV activity [32]. (D) Time course of inactivation of phosphorylated CaMKIV by PP2A [33]. (E) Time course of Total_pCaMKIV in presence of 90 mM K+ solution for 1 min [39]. (F) Time course of active PKA in presence of LTP (three sets of stimuli at 10 min intervals, each set consisting of three 1 sec, 100 Hz tetani, 5 sec apart) [42].