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. 2014 May 1;9(5):e95154. doi: 10.1371/journal.pone.0095154

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© 2014 Jain, Bhalla

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The reference model parameter was varied by 0.1 to 10 fold to measure mRNA synthesis rate. The measured value was divided by the reference parameter model value to obtain the fold change. The parameters which show greater than two fold change in the response are plotted. The measurements done at 1000(A) Sensitivity Analysis for intial concentration (CoInit) (B) Sensitivity Analysis for Michaelis constant for enzymatic reactions (Km). (C) Sensitivity Analysis for turn over number for enzymatic reactions (kcat). (D) Sensitivity Analysis for forward rate of binding reations (Kf). (E) Sensitivity Analysis for backward rate for binding reactions (Kb).