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. 2014 May 1;9(5):e95154. doi: 10.1371/journal.pone.0095154

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© 2014 Jain, Bhalla

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Calcium dose-response relationship for mRNA synthesis rate (A) and Total_MAPK (B). (C) The rise in mRNA synthesis is negligible when BDNF input is combined with LTP stimulus (D) mRNA synthesis responds more strongly when BDNF was combined with LTD stimulus. (E) Control and knockout responses to LTP stimulus. (F) Control and knockout responses to LTD stimulus. CREB and TORC1 knockouts completely abolished the mRNA response as they are immediate upstream regulators. CaMKIV and MAPK knockouts had intermediate effects on mRNA. (G) Temporal tuning of pCREB-CRE and TORC1n. (H) Temporal tuning of mRNA synthesis rate. We plotted area under the curve after the stimulus presentation for Fig. 6G and 6H.