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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Clin Pharmacol Ther. 2013 Apr 10;94(2):243–251. doi: 10.1038/clpt.2013.80

Figure 1.

Figure 1

Receiver operating characteristic curves of clinical and genetic variables for the prediction of cisplatin-induced hearing loss in the combined cohort (n = 317). (a) Clinical variables are age, vincristine treatment, germ-cell tumor, and cranial irradiation, whereas genetic variables combine the effect of TPMT rs12201199, COMT rs4646316, and ABCC3 rs1051640. (b) The area under the curve for the combined cohort for each model. The P-values indicate the statistical significance between the curves for the combination of genetic and clinical variables as compared with clinical variables alone. CI, confidence interval; SNP, single-nucleotide polymorphism.