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. 2014 May 1;9(5):e96192. doi: 10.1371/journal.pone.0096192

Figure 1. Pedigree, haplotype analysis, and mutation analysis of the families in this study.

Figure 1

A: Pedigree and disease-haplotype segregation of family A. Blackened symbols represent affected individuals with an abnormal limb phenotype. White symbols represent individuals with a normal limb phenotype. Circles and squares indicate females and males, respectively. The arrows identify the proband and the disease-haplotype is boxed. B: Pedigree and disease-haplotype segregation of family B. C: HOXD13 missense mutations in the two families.