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. 2014 May 1;9(5):e96060. doi: 10.1371/journal.pone.0096060

Figure 5. The effect of ERK1/2 inhibition on PTK6-induced cellular migration and invasion.

Figure 5

A, Cells were treated with the specific ERK1/2 inhibitor, U0126 at 10 µM for 24 hours. ERK1/2 phosphorylation was inhibited and PTK6-induced activation of ERK1/2 was no longer detected in Panc1 or MIAPaCa2 cells. B , The effect of ERK1/2 inhibition on cellular migration (left) and invasion (right) ERK1/2 inhibition not only reduced basal migration and invasion in Panc1 and MIAPaCa2 cells, but abolished the effect of PTK6-overexpression on migration and invasion. *p<0.05 vs corresponding control with DMSO vehicle (by t-test). **p<0.05 vs PTK6-overexpressed cells with DMSO vehicle (by t-test). Each assay was performed in triplicate.