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. 2014 May 1;10(5):e1004082. doi: 10.1371/journal.ppat.1004082

Figure 6. Differential importance of cytoplasmic sensors in inflammasome response to HIV and HCV.

Figure 6

Functional knockdowns of the cytoplasmic sensors NLRP3, RIG-I and AIM2 in monocytes were created as previously described for TLRs. (A) Knockdown monocytes were cultured with HIVBaL, HIVRF, HIVIIIB, or HIVRF and IL-18 measured after 24 h. IL-18 produced relative to that of mock transfected cells is shown. (B) Similarly prepared monocytes were cultured with a panel of plasma from HCV infected individuals (HCVSubject 117, HCVSubject 54, HCVSubject 16, HCVSubject 180) and IL-18 measured at 24 h. Bars represent the mean ± S.D. for n = 6–9 independent transfection experiments.