. 2014 May 1;9(5):e94864. doi: 10.1371/journal.pone.0094864

Table 1. Characteristics of the study participants in the validation datasets.

	Discovery set			Validation set I			Validation set II
Characteristic	HCC (n = 29)^*	Non-HCC (n = 35)^*	P	HCC (n = 97)^*	Non-HCC (n = 97)^*	P	HCC (n = 105)^*	Non-HCC (n = 105)^*	P
Age, mean ± SD	51.9±8.9.	52.2±9.4	Matched	52.6±12.5	52.0±9.0	Matched	49.8±9.7	48.7±9.5	Matched
Sex, male	22 (75.9)	26 (74.3)	Matched	73 (75.3)	74 (76.3)	Matched	90 (85.7)	90 (85.7)	Matched
HBeAg positive	11 (37.9)	8 (22.9)	0.189	32 (33.3)	22 (22.9)	0.108	39 (37.1)	28 (26.7)	0.103
Serum HBV DNA level (log₁₀ copies/mL ≥5)	15 (51.7)	17 (48.6)	0.802	49 (50.5)	46 (47.4)	0.667	56 (53.3)	58 (55.2)	0.782
Serum ATL level (>40 IU/L)	17 (58.6)	3 (8.6)	<0.001	67(69.1)	6 (6.2)	<0.001	37 (35.2)	9 (8.6)	<0.001

Abbreviations: ALT, alanine aminotransferase; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; HCC, hepatocellular carcinoma.

*Data are presented as n (%), unless otherwise indicated.