Table 2. Discovery of candidate mutations associated with hepatocellular carcinoma in the reverse transcriptase domain of hepatitis B virus.
| Amino acid change | ||||||
| Nucleotide mutation | P ORF | S ORF | Location of RT domain | HCC (n = 29)* | Non-HCC (n = 35)* | P |
| C294T | NC (NC) | T48M | Space F-A | 3 (10.3) | 0 (0.0) | 0.088 |
| C300G | NC (NC) | P49R | Space F-A | 3 (10.3) | 0 (0.0) | 0.088 |
| T555C | NC (NC) | F134S | Space B-C | 3 (10.3) | 0 (0.0) | 0.088 |
| T766A | S559T (rtS213T) | S204R | Space C-D | 3 (10.3) | 0 (0.0) | 0.088 |
| A799G | I570V (rtI224V) | NC | Space C-D | 6 (20.7) | 0 (0.0) | 0.006 |
| T843C | NC (NC) | NA | Domain E | 9 (31.0) | 4 (11.4) | 0.066 |
| T870C | NC (NC) | NA | Domain E | 4 (13.8) | 0 (0.0) | 0.037 |
| T895A | C620S (rtC256S) | NA | Space E-end | 12 (41.4) | 7 (20.0) | 0.098 |
| T906R | NC (NC) | NA | Space E-end | 2 (6.9) | 8 (22.9) | 0.097 |
| C936T | NC (NC) | NA | Space E-end | 9 (31.0) | 3 (8.6) | 0.028 |
| A942S | H617Q (rtH271Q) | NA | Space E-end | 2 (6.9) | 8 (22.9) | 0.097 |
| A987G | NC (NC) | NA | Space E-end | 6 (20.7) | 1 (2.9) | 0.061 |
| T1055A | M655K (rtM309K) | NA | Space E-end | 3 (10.3) | 0 (0.0) | 0.088 |
| T1069A | C660S (C314S) | NA | Space E-end | 4 (13.8) | 0 (0.0) | 0.037 |
| T1071C | NC (NC) | NA | Space E-end | 3 (10.3) | 0 (0.0) | 0.088 |
Abbreviations: NA, not available, NC, not changed; rt, reverse transcriptase; P, polymerase; S, surface antigen; ORF, open reading frame.
*Data are presented as n (%).