Table I. Baseline characteristics, by incident hospitalization.
Overall (n = 9484) |
No hospitalization (n = 6521) |
Any hospitalization (n = 2963) |
P | |
---|---|---|---|---|
Age (y) | 75 (67–82) | 75 (67–81) | 76 (68–82) | <.0001 |
Female | 43 | 42 | 44 | .046 |
Race | .17 | |||
White | 90 | 89 | 91 | |
Black or African American | 4.7 | 4.8 | 4.6 | |
Hispanic | 4.1 | 4.3 | 3.6 | |
Other | 1.4 | 1.5 | 1.2 | |
Health insurance status | .0002 | |||
Medicare or Medicaid | 70 | 69 | 73 | |
Private | 25 | 26 | 22 | |
Other | 4.7 | 4.8 | 4.4 | |
Hypertension | 83 | 82 | 85 | .0006 |
Hyperlipidemia | 73 | 72 | 74 | .12 |
Diabetes | 29 | 27 | 35 | <.0001 |
Peripheral vascular disease | 13 | 12 | 17 | <.0001 |
Coronary artery disease | 33 | 29 | 39 | <.0001 |
Heart failure | <.0001 | |||
None | 67 | 72 | 57 | |
NYHA I | 10 | 9.9 | 11 | |
NYHA II | 15 | 13 | 20 | |
NYHA III/IV | 7.4 | 5.5 | 11 | |
Prior cerebrovascular events (stroke or TIA) | 15 | 14 | 17 | <.0001 |
Left ventricular ejection fraction | <.0001 | |||
>50% | 70 | 72 | 68 | |
40%–50% | 6.3 | 5.8 | 7.5 | |
30%–40% | 8.9 | 7.9 | 11 | |
<30% | 4.3 | 3.6 | 5.7 | |
Calculated glomerular filtration rate (mL/min per 1.73 m2 | 67 (53–82) | 68 (55–83) | 64 (50–79) | <.0001 |
AF type at baseline | 0.54 | |||
New onset | 4.4 | 4.3 | 4.7 | |
Paroxysmal | 51 | 51 | 50 | |
Persistent | 17 | 17 | 17 | |
Long-standing persistent | 28 | 28 | 29 | |
EHRA symptom class | <.0001 | |||
None | 38 | 40 | 33 | |
Mild | 45 | 45 | 46 | |
Severe | 15 | 13 | 18 | |
Disabling | 1.8 | 1.8 | 1.8 | |
CHADS2 score, mean (SD) | 2.3 (1.3) | 2.2 (1.3) | 2.5 (1.3) | <.0001 |
Antiarrhythmic therapy at baseline | 29 | 28 | 31 | .003 |
Any oral anticoagulant | 77 | 76 | 78 | .14 |
Oral anticoagulant* | .39 | |||
None | 23 | 24 | 22 | |
Warfarin | 72 | 71 | 73 | |
Dabigatran | 4.8 | 4.9 | 4.8 | |
Percent time in therapeutic range (INR 2-3), median (IQR) | 62 (41–80) | 65 (45–83) | 54 (36–73) | <.0001 |
Percent time INR <2, median (IQR) | 19 (4–37) | 17 (0–34) | 25 (9–43) | <.0001 |
Percent time INR >3, median (IQR) | 9 (0–23) | 9 (0–22) | 12 (0–26) | <.0001 |
Values are presented as % or median (interquartile range), unless noted otherwise. Time in therapeutic range was calculated using the Rosendaal method.10
Abbreviations: TIA, transient ischemic attack; IQR, interquartile range.
No patients were on rivaroxaban or apixaban at baseline.