Table II. Predictors of first all-cause hospitalization.
| Adjusted HR (95% CI) |
t Value | P | |
|---|---|---|---|
| NYHA class III/IV | 1.57 (1.38–1.78) | 6.80 | <.0001 |
| Increased heart rate (>66), per 10 beats/min | 1.11 (1.07–1.16) | 5.36 | <.0001 |
| NYHA class II | 1.35 (1.21–1.51) | 5.28 | <.0001 |
| EHRA severe | 1.37 (1.21–1.55) | 5.09 | <.0001 |
| COPD | 1.23 (1.12–1.34) | 4.37 | <.0001 |
| Prior treatment with antiarrhythmic drug | 1.16 (1.07–1.27) | 3.62 | .0003 |
| Prior MI | 1.17 (1.07–1.29) | 3.28 | .001 |
| Peripheral vascular disease | 1.18 (1.07–1.31) | 3.31 | .0009 |
| History of PCI | 1.18 (1.07–1.30) | 3.34 | .0008 |
| Diabetes | 1.13 (1.05–1.22) | 3.22 | .001 |
| NYHA class I | 1.21 (1.07–1.36) | 3.13 | .002 |
| EHRA mild | 1.16 (1.06–1.28) | 3.22 | .001 |
| Not living independently | 1.24 (1.09–1.42) | 3.29 | .001 |
| Obstructive sleep apnea | 1.16 (1.05–1.28) | 2.94 | .003 |
| Severe LAE | 1.21 (1.07–1.36) | 3.03 | .003 |
| Anemia | 1.15 (1.05–1.26) | 2.95 | .003 |
| Hypothyroidism | 1.11 (1.03–1.20) | 2.77 | .006 |
| Cancer | 1.12 (1.03–1.21) | 2.70 | .007 |
| Frailty | 1.20 (1.05–1.39) | 2.61 | .009 |
| Moderate LAE | 1.11 (0.99–1.25) | 1.73 | .08 |
| Mild LAE | 1.07 (0.94–1.20) | 1.02 | .3 |
| EHRA disabling symptoms | 1.06 (0.78–1.45) | 0.39 | .7 |
| Increased heart rate (≤66), per 10 beats/min | 0.89 (0.80–0.99) | −2.07 | .04 |
| Increased diastolic blood pressure, per 10 mm Hg | 0.95 (0.91–0.99) | −2.42 | .02 |
| Increased hematocrit, per 10% | 0.83 (0.76–0.90) | −4.40 | <.0001 |
c Index = 0.63.
Abbreviations: COPD, chronic obstructive lung disease; PCI, percutaneous coronary intervention; CHF, congestive heart failure; LAE, left atrial enlargement.