Table 4.
Risk of Overall and Colon Cancer–Specific Mortality Stratified According to Preexisting Mental Disorder*
| Type of Mental Disorder | Hazard Ratio (95% Confidence Interval) | |
|---|---|---|
| Overall Mortality | Colon Cancer-Specific Mortality | |
| Any mental disorder | ||
| Unadjusted | 1.55 (1.52–1.58) | 1.31 (1.27–1.35) |
| Model 1 | 1.44 (1.41–1.47) | 1.23 (1.19–1.27) |
| Model 2 | 1.33 (1.31–1.36) | 1.23 (1.19–1.27) |
| Mood disorder | ||
| Unadjusted | 1.08 (1.05–1.12) | 1.02 (0.97–1.06) |
| Model 1 | 1.11 (1.08–1.15) | 1.03 (0.99–1.08) |
| Model 2 | 1.07 (1.03–1.10) | 1.04 (0.99–1.10) |
| Psychotic disorder | ||
| Unadjusted | 1.39 (1.33–1.46) | 1.27 (1.20–1.36) |
| Model 1 | 1.30 (1.24–1.36) | 1.19 (1.11–1.27) |
| Model 2 | 1.22 (1.17–1.28) | 1.16 (1.10–1.24) |
| Dementia | ||
| Unadjusted | 2.01 (1.95–2.10) | 1.75 (1.67–1.83) |
| Model 1 | 1.60 (1.55–1.66) | 1.49 (1.42–1.56) |
| Model 2 | 1.45 (1.40–1.50) | 1.41 (1.34–1.48) |
| Substance use disorder | ||
| Unadjusted | 1.21 (1.15–1.26) | 1.04 (0.97–1.10) |
| Model 1 | 1.37 (1.31–1.43) | 1.14 (1.06–1.21) |
| Model 2 | 1.26 (1.20–1.32) | 1.12 (1.04–1.20) |
| Other mental disorder | ||
| Unadjusted | 1.07 (1.03–1.10) | 1.01 (0.96–1.05) |
| Model 1 | 1.06 (1.02–1.09) | 0.99 (0.95–1.04) |
| Model 2 | 1.04 (1.01–1.08) | 1.03 (0.99–1.08) |
As defined in Measures section.
Analyses excluded patients whose colon cancer was diagnosed at autopsy.
Model 1 adjusted for age; race and ethnicity; sex; marital status; Surveillance, Epidemiology and End Results region; income; and year of diagnosis.
Model 2 additionally adjusted for comorbid disease index and cancer stage at diagnosis index.