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. 2014 Apr 27;7:45. doi: 10.1186/1757-2215-7-45

Table 2.

Antiprogestin-induced growth inhibition toward CDDP and PTX resistant cells

Cells RU-38486 ORG-31710 CDB-2914 CDB-4124 OH-4124 CDB-4453
IGROV-1
11.7 ± 1.80
21.6 ± 1.10
15.5 ± 1.10
35.5 ± 3.90
28.6 ± 3.40
30.6 ± 2.70
IGROV-1 PTES
10.7 ± 1.20
15.2 ± 1.40c
12.5 ± 1.10
21.3 ± 1.80c
25.9 ± 2.40
25.6 ± 2.60
SKOV-3
15.7 ± 1.90
17.2 ± 4.20
31.5 ± 3.10
43.6 ± 5.10
84.2 ± 9.80
44.9 ± 4.60
SKOV-3 PTES 16.0 ± 2.10 19.2 ± 2.70 31.2 ± 1.80 47.4 ± 3.90 58.4 ± 8.30 52.9 ± 2.10

Data shown are the IC50 (μM) expressed as the mean ± s.e.m (n = 3); OH-4124 indicates 17-α-hydroxy CDB-4124. cp < 0.05 (Student’s t-test) compared to parental cells.