Table 2.
Antiprogestin-induced growth inhibition toward CDDP and PTX resistant cells
| Cells | RU-38486 | ORG-31710 | CDB-2914 | CDB-4124 | OH-4124 | CDB-4453 |
|---|---|---|---|---|---|---|
| IGROV-1 |
11.7 ± 1.80 |
21.6 ± 1.10 |
15.5 ± 1.10 |
35.5 ± 3.90 |
28.6 ± 3.40 |
30.6 ± 2.70 |
| IGROV-1 PTES |
10.7 ± 1.20 |
15.2 ± 1.40c |
12.5 ± 1.10 |
21.3 ± 1.80c |
25.9 ± 2.40 |
25.6 ± 2.60 |
| SKOV-3 |
15.7 ± 1.90 |
17.2 ± 4.20 |
31.5 ± 3.10 |
43.6 ± 5.10 |
84.2 ± 9.80 |
44.9 ± 4.60 |
| SKOV-3 PTES | 16.0 ± 2.10 | 19.2 ± 2.70 | 31.2 ± 1.80 | 47.4 ± 3.90 | 58.4 ± 8.30 | 52.9 ± 2.10 |
Data shown are the IC50 (μM) expressed as the mean ± s.e.m (n = 3); OH-4124 indicates 17-α-hydroxy CDB-4124. cp < 0.05 (Student’s t-test) compared to parental cells.