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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: Nat Rev Cancer. 2011 May 19;11(6):450–457. doi: 10.1038/nrc3063

Figure 2. Dissemination of metastasis early and late during tumour progression.

Figure 2

Metastatic spread may occur throughout tumour progression, both early in tumour evolution and as the tumour evolves more genetic alterations. The metastases may then evolve to develop metastasis-specific mutations that are different to those found in the primary tumour.