Skip to main content
. Author manuscript; available in PMC: 2014 Oct 17.
Published in final edited form as: Nature. 2014 Apr 9;508(7496):340–344. doi: 10.1038/nature13231

Figure 1. Approaches to constructing acyclic all-carbon quaternary stereocenters.

Figure 1

a, Conventional enantioselective, catalytic approaches. α-functionalization of carbonyls (I). β-functionalization of carbonyls (II). α-quaternary centers adjacent to alkene (III). b, Proposed modular strategy using a redox relay enantioselective Heck reaction of trisubstituted alkenes and resulting mechanistic analysis.