Fig. 4. LCA and LCE inhibit LXRα-/RXRα-dependent LXREluciferase activity. LXRE-luciferase transactivation was determined using lysates of HepG2 cells treated with LCA or LCE for 12 hr after transfection of plasmids encoding for LXRα and RXRα. Data represent the mean ± S.E. of 4 separate experiments. The statistical significance of differences between each treatment group and the control (##p< 0.01) or T090 without LCA or LCE (**p< 0.01) was determined.
