Table 9.
Approaches to Treatment of Diabetic Diarrhea
| Treatment | Dose Regimen | Possible Side Effects |
|---|---|---|
|
| ||
| Exclude other underlying causes: | ||
| Bacterial overgrowth | ||
| Drug-related (acarbose, metformin, lactose intolerance) | ||
| Osmotic (resolves with fasting) | ||
| Secretory (consider neuroendocrine tumors) | ||
|
| ||
| Metronodiazole | 250 mg, TID, ≥ 3 wk | Fungal overgrowth |
|
| ||
| Clonidine | 0.1 mg, BID or TID | Orthostatic hypotension |
|
| ||
| Loperamide | 2 mg, QID | Toxic megacolon |
|
| ||
| Cholestyramine | 4 g, 1 to 6 times daily | |
|
| ||
| Octreotide | 50 μg, TID | Aggravated nutrient malabsorption |