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. 2014 May 2;4:4873. doi: 10.1038/srep04873

Figure 2. Maternal transmission of increased Gαq expression.

Figure 2

(a) Data are mean ± sem (N = 6–8/group; equal numbers of males and females) of real-time RT-PCR measures. A comparison between SFR, IMS, and theophylline-treated IMS (IMS-tph) Balb/c mice (ANOVA (F(2,18) = 8.338; p = 0.0033; post hoc Tukey-Kramer multiple comparisons)) revealed significantly increased Gαq mRNA expression in IMS Balb/c mice that was reversed by adolescent theophylline treatment. Further comparison between SFR, F2 progenies of IMS fathers and mothers, F2 progenies of IMS mothers treated with theophylline (F2-tph), and F3 and F4 progenies of IMS mothers mice revealed significant differences (ANOVA (F(5,45) = 3.234; p = 0.0152) that were resolved post hoc only for the F2 progeny of IMS mothers that exhibited increased Gαq mRNA expression. (b) Gαq mRNA levels in cross-fostered mice. Significant differences revealed by ANOVA, F(2,17) = 12.22, p = 0.0007)) were resolved post hoc for F2-RevCF mice that exhibited increased Gαq expression.