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Pyruvate activation of signaling kinases in neuronal cells. Panel A: Phosphorylation of mTOR and p70S6 kinase was assessed by immunoblot at 4 h reoxygenation after 3 and 6 h of OGD. p70S6 kinase was activated by rtPA administered after 3 h OGD, but inactivated by delayed rtPA treatment. Pyruvate±rtPA activates p70S6 kinase in OGD both protocols. Panel B: Pyruvate but not rtPA phosphor-activates Akt and Erk.
