Figure 3.

Inhibition of SK diminishes MCF-7 clonogenic survival. MCF-7 cells were plated at 1000 cells/well in six-well plates. Twenty-four hours later cells were treated with DMSO (vehicle) or SKI-II (0·1–10 μM) for 14 days. Colonies of >30 were counted as positive. Results were normalized to percent clonogenic survival of vehicle control cells. Data represented as mean±s.e.m. of three independent experiments.