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. Author manuscript; available in PMC: 2014 May 2.
Published in final edited form as: J Mol Endocrinol. 2011 Apr 28;46(3):205–216. doi: 10.1530/JME-10-0116

Figure 5.

Figure 5

Inhibition of SK decreases estrogen signaling in vitro. HEK293 (A) or MCF-7 (B) cells were transiently transfected with pGl2-ERE2X-TK-luciferase plasmid. HEK293 cells were additionally transfected with pcDNA3.1B-ERα plasmid. Subsequently, the cells were treated with DMSO (control), estrogen (E2) or SKI-II. Cells treated with E2 were set to 1. (C) Effect of SKI-II (10 μM) on ERα, PGR and SDF-1 gene expression. Statistical analysis was performed comparing treatment groups with E2 control (***P<0·001, *P<0·05).