Figure 2.

Kallikrein gene delivery significantly activates cell proliferation signaling pathways in SHRs. The protein levels of phosph-ERK1/2, phosph-AKT, and PI3K were detected by Western blotting (A), and the expression levels, as determined by densitometry, were normalized to total ERK1/2, AKT, and β-actin (B, C, D). The histogram displays the significant increase of p-ERK1/2, p-AKT, and PI3K in rAAV-HK-treated SHR compared with rAAV-lacZ control group. ^cP<0.01