Figure 3.

The kallikrein/kinin system inhibits apoptosis by modulating the bcl-2 protein family. Protein expression levels in the tissue samples were detected by Western blot analysis (A). Blots were scanned and the relative expression levels, as determined by densitometry, were normalized to total β-actin as shown in the histogram (B, C, D). Kallikrein gene delivery significantly increased the protein levels of bcl-2, and bcl-x_L two anti-apoptotic proteins, and decreased the protein level of Bax, a pro-apoptotic protein. ^cP<0.01 vs rAAV-LacZ group.