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. 2009 Aug 17;30(9):1253–1261. doi: 10.1038/aps.2009.114

Figure 8.

Figure 8

The kallikrein/Kinin system inhibits apoptosis by affecting the bcl-2 protein family in HEK 293 cells. Western blot analysis was performed on lysates from cells in non-FBS medium exposed to LPS (A), and the relative expression levels, as determined by densitometry, were normalized to total β-actin, as shown in the histograms (B, C, D). When exposed to LPS in non-FBS medium, the protein levels of bcl-2 and bcl-xL in HEK 293 cells decreased while the protein level of bax increased. However, treatment with rAAV-HK and kinin, but not lacZ or Kinin+Hoe140, attenuated the effects of LPS on the expression levels of the bcl-s family. cP<0.01 vs rAAV-LacZ group.