Table 2. Prevalence of OHT and OH among genotypes in hypertensive patients.
| Genotype frequencies n (%) | Allele frequencies n (%) | |||||||
|---|---|---|---|---|---|---|---|---|
| n | MM | Mm | mm | P* (r/d) | M | m | P | |
| ACE2 rs2106809 | CC | CT | TT | C | T | |||
| Female | ||||||||
| ONT | 1449 | 594 (40.9) | 647 (44.7) | 208 (14.4) | – | 1835 (63.3) | 1063 (36.7) | – |
| OHT | 358 | 139 (39.7) | 165 (46.1) | 54 (15.1) | 0.75 (0.73/0.45) | 443 (61.9) | 273 (38.1) | 0.47 |
| OH | 564 | 239 (42.4) | 247 (43.8) | 78 (13.8) | 0.84 (0.76/0.57) | 725 (64.3) | 403 (35.7) | 0.57 |
| Male | ||||||||
| ONT | 737 | 473 (64.2) | 264 (35.8) | – | ||||
| OHT | 196 | 129 (65.8) | 67 (34.2) | 0.67 | ||||
| OH | 269 | 167 (62.1) | 102 (37.9) | 0.54 | ||||
| ACE2 rs2285666 | AA | AG | GG | A | G | |||
| Female | ||||||||
| ONT | 1453 | 425 (29.2) | 710 (48.9) | 318 (21.9) | – | 1560 (54.1) | 1326 (45.9) | – |
| OHT | 361 | 118 (32.7) | 161 (44.6) | 82 (22.7) | 0.31 (0.73/0.20) | 397 (55.0) | 325 (45.0) | 0.65 |
| OH | 569 | 157 (27.6) | 270 (47.5) | 142 (25.0) | 0.32 (0.14/0.46) | 584 (51.3) | 554 (48.7) | 0.11 |
| Male | ||||||||
| ONT | 742 | 417 (56.2) | 325 (43.8) | – | ||||
| OHT | 199 | 104 (52.3) | 95 (47.7) | 0.32 | ||||
| OH | 270 | 159 (58.9) | 111 (41.1) | 0.44 | ||||
| ACE I/D | II | ID | DD | I | D | |||
| Female | ||||||||
| ONT | 1459 | 541 (37.1) | 688 (47.2) | 230 (15.8) | – | 1770 (60.7) | 1148 (39.3) | – |
| OHT | 362 | 125 (34.5) | 166 (45.9) | 71 (19.6) | 0.20 (0.08/0.37) | 416 (57.5) | 308 (42.5) | 0.11 |
| OH | 565 | 208 (36.8) | 264 (46.7) | 93 (16.5) | 0.93 (0.7/0.91) | 680 (60.2) | 450 (39.8) | 0.77 |
| Male | ||||||||
| ONT | 742 | 258 (34.8) | 347 (46.8) | 137 (18.5) | – | 863 (58.2) | 621 (41.8) | – |
| OHT | 201 | 69 (34.3) | 92 (45.8) | 40 (19.9) | 0.89 (0.64/0.91) | 230 (57.2) | 172 (42.8) | 0.73 |
| OH | 272 | 85 (31.3) | 132 (48.5) | 55 (20.2) | 0.55 (0.53/0.29) | 302 (55.5) | 242 (44.5) | 0.29 |
OHT indicates orthostatic hypertension; OH, orthostatic hypotension; ONT, orthostatic normotension; M, major allele, m, minor allele, of each polymorphism. χ2 test vs ONT group;
*
indicates P values under additive model; (r/d), P values under recessive/dominant models.