Table S1. Orthostatic BP changes among genotypes in normotensive subjects.

Orthostatic BP change	Women				Men
ACE2 rs2106809	CC n=267	CT n=206	TT n=56	P	C n=180	T n=102		P
ΔSBP0, mmHg	−3.5 (−5.2– −2.1)	−4.3 (−6.1– −2.3)	−4.6 (−6.3– −2.7)	0.84	−2.0 (−3.6–0.7)	−1.2 (−3.1–1.4)		0.80
ΔDBP0, mmHg	0.3 (−1.3–1.6)	0.8 (−1.4–1.9)	0.6 (−1.5–1.8)	0.35	1.1 (−0.9–2.3)	1.8 (−0.6–3.2)		0.71
ΔSBP2, mmHg	−2.4 (−4.5– −1.3)	−3.0 (−5.1– −1.5)	−3.2 (−5.4– −1.4)	0.24	−2.6 (−4.8– −0.1)	−0.4 (−2.7–3.4)		0.36
ΔDBP2, mmHg	0.87 (−0.7–2.1)	1.1 (0.3–2.1)	0.91 (−0.6–2.0)	0.43	1.8 (−0.1–3.3)	3.7 (1.2–5.2)		0.34
ACE2 rs2285666	AA n=150	AG n=262	GG n=122		A n=157	G n=127
ΔSBP0, mmHg	−3.4 (−5.6– −1.2)	−4.5 (−6.6– −2.3)	−4.2 (−6.2– −2.1)	0.78	−2.7 (−4.3– −0.1)	−3.0 (−4.6– −0.9)		0.86
ΔDBP0, mmHg	0.2 (−1.3–1.1)	0.5 (−1.4–1.9)	−1.1 (−0.5–1.9)	0.17	0.4 (−1.5–1.9)	0.7 (−0.6–1.7)		0.87
ΔSBP2, mmHg	−2.8 (−4.5– −1.4)	−3.8 (−4.9– −1.7)	−3.4 (−5.6– −1.2)	0.79	−1.7 (−3.3– −0.1)	−3.0 (−4.3–0.3)		0.51
ΔDBP2, mmHg	1.3 (−0.3–2.1)	0.9 (−0.7–1.9)	−1.0 (−1.9–0.1)	0.15	1.7 (−0.2– 2.7)	2.5 (0.9–3.6)		0.58
ACE I/D	II n=176	ID n=249	DD n=110		II n=92	ID n=143	DD n=48
ΔSBP0, mmHg	−3.5 (−5.9– −1.1)	−4.4 (−6.1– −2.2)	−6.8 (−8.9– −3.5)	0.24	−4.5 (−6.9– −2.1)	−2.9 (−5.1– −0.3)	−3.6 (−5.8– −0.6)	0.81
ΔDBP0, mmHg	−1.9 (−3.2– −0.3)	−1.1 (−2.5–0.1)	−1.2 (−3.6–0.7)	0.80	−0.2 (−1.6–1.9)	0.64 (−1.4–2.4)	−1.1 (−2.3–0.8)	0.51
ΔSBP2, mmHg	−3.9 (−6.2– −1.7)	−3.6 (−5.1– −1.8)	−4.2 (−7.8– −2.9)	0.94	−3.9 (−6.1– −1.3)	−1.7 (−3.5–0.3)	−5.2 (−7.1– −2.9)	0.24
ΔDBP2, mmHg	−1.2 (−2.9–0.1)	0.2 (−1.3–1.8)	−0.2 (−2.1–1.3)	0.59	1.6 (−0.5–2.8)	2.2 (0.9–3.8)	−0.7 (−2.5–1.6)	0.26

CSBP0 indicates systolic blood pressure changes at 0 min after standing; ΔSBP2, systolic blood pressure changes at 2 min after standing; ΔDBP0 or 2, diastolic blood pressure changes at 0 or 2 min after standing. Data are expressed as mean (95% CI of differences).